Synthesis, Characterization and Anticonvulsant Activity of New 4-thiazolidinone and 1,2,4-triazole- 3-thione Derivatives
Published in Acta Pharmaceutica Turcica, 1998
A series of new 2-[[[[4-phenyl-5-(2-furyl)-1,2,4-triazol-3- yl] thio] acetyl] hydrazono] -3 - alkyl/aryl - 4 - thiazolidinones (3a-h) and 4-alkyl/aryl-2,4-dihydro- 5-[[[4-phenyl-5-(2-furyl)-1,2,4-triazol-3-yl]-thio] methyl]-3H-1,2,4-triazole -3-thiones (4a-h) were synthesized, characterized and evaluated for anticonvulsant activity against pentylenetetrazole induced seizures. Among the tested compounds, the highest protection (40%) was demonstrated by the 4-allyl substituted derivative 4d.
Recommended citation: N. Ulusoy, G. Capan, N. Ergenc, A.C. Ekinci, A. Vidin, Synthesis, characterization and anticonvulsant activity of new 4- thiazolidinone and 1,2,4-triazole-3-thione derivatives, Acta Pharmaceutica Turcica. 40 (1998) 5–8.
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